Guide language: conservative is a comfortable product, only breakthrough and innovation can make all science and technology to progress continuously. Breaking through the shackles of traditional thinking and walking out of a road of innovation in the future world is an era of opportunities and challenges coexist, and also an era of relying on innovation to win the future. This is the development direction of the pharmaceutical industry, but also belongs to the responsibility and responsibility of every one of us.

On June 11th, the 2022 15th Times Technology Forum (hereinafter referred to as the Forum), hosted by Time Engineering Technology Group Co., Ltd. and organized by Dandelion and China Pharmaceutical Manufacturing Industry Alliance, was held in the cloud for China Pharmaceutical Intelligent Manufacturing Industry Alliance. With the theme of "Refactoring the new pharmaceutical ecology with freshmen", this forum gathers the ecological strength of industry, university and research, and helps the low-carbon intelligent upgrade of the pharmaceutical industry. Professional audience of 16,504 people watched it online, and industry experts look for new life and see the future.

The forum was presided over by Mr.Zhang Jinwei, founder of Dandelion and vice chairman of the organizing committee of The Times Science and Technology Forum.

 

Zhang Jinwei, host of The Technology Forum

Mr.Wu Yafeng, director, president and chief designer of The All Times Group, delivered the opening speech for the forum. Wu Yafeng said that 2022 is the modern technology BBS with industry colleagues in 15 years, is also a chemical pharmaceutical and biological pharmaceutical enterprise break the key to the new year, hope the pharmaceutical companies can through the modern technology BBS to accelerate the depth of science and technology and production practice, boost enterprise transformation and upgrading and industrial sustainable development.

 

All-Times Group President Wu Yafeng delivered the opening speech

Experts say- -unlocking the future direction of pharmaceuticals The forum invited well-known industry experts, college scholars and enterprises from home and abroad to systematically discuss around the "fourteenth Five-year Plan" pharmaceutical planning, unmanned environmental protection factory, micro-chemical industry and continuous flow, international frontier biological factory design concept, bioreactor, information landing six industry hot topics. During the 13th Five-Year Plan period, pharmaceutical innovation has advanced by leaps and bounds, industrial concentration degree has been further enhanced, and pharmaceutical exports have achieved rapid growth. However, there are problems such as unbalanced development of various sub-industries, intensified business differentiation, and slow upgrading of export structure. Mr.Wang Xuegong, executive vice President of China Pharmaceutical Enterprise Management Association, delivered a keynote speech on the Analysis of the Development situation of pharmaceutical Industry in the 14th Five-Year Plan period. Wang Xuegong said that the 14th Five-Year Plan period is a key period for the restructuring of the pharmaceutical industry, the innovation-driven development and transformation, and the key period for the establishment of a new growth model and a new industrial pattern. At this stage, when various forces stalemate and game, the industry may usher in great changes in development. Wang Xuegong stressed that during the 14th Five-Year Plan period, the focus is to accelerate the innovation-driven transformation, build industrial chain advantages, improve the manufacturing level, improve the drug supply guarantee system, build international competitive advantages, and build a high-value, high-level and international Chinese pharmaceutical market.

 

Wang Xuegong delivered a keynote speech on the analysis of the Development situation of the pharmaceutical industry in the 14th Five-year Plan period

Dr. Chen Ping, director, vice president and chief technology Officer of Times Group, delivered a keynote speech on "Intelligent Lean of sewage treatment Workshop of Chemical Enterprises". He introduced the problems and countermeasures of environmental protection workshop, pollutant degradation and case review, SND technology, intelligent control and energy saving and consumption reduction and emission reduction planning. Dr Chen ping said, through accurate aeration, accurate dosing (phosphorus), accurate fenton reduce mud, stable water precise control, hydrolysis acidification accurate control intelligent control means, pharmaceutical enterprise environmental protection workshop can achieve efficiency, cost drop, the production safety, increasingly lean management, decision-making more dynamic, finally realize green intelligence in the future.

 

Chen Ping made a keynote speech on "intelligent lean sewage treatment workshop of chemical enterprises"

Luo Guangsheng, professor of Tsinghua University and director of the State Key Laboratory, delivered a keynote speech on "Micro Chemical Technology and Continuous Flow Synthesis". Professor Luo Guangsheng first introduced the urgent demand for new technologies, new equipment and new processes in the current chemical industry from the challenges faced by the institute of chemical production and chemical synthesis. Then Professor Luo Guangsheng explained the micro-chemical technology in detail, saying that the technology is a continuous efficient and controllable reaction and separation process in the micron or sub-millimeter limited space, and with the "quantity amplification" as the basic criterion, the laboratory results are directly applied to industrial processes, so as to realize the scale preparation of chemicals. For the pharmaceutical industry, how to make the batch production continuous is also a hot topic of research in recent years. In the second half of the course, he introduced the development direction of chemical continuous synthesis technology from the intermittent process continuity and the complex multi-step reaction continuity, which provided a strong theoretical support for the continuous production exploration of the pharmaceutical industry.

 

Luo Guangsheng delivered a keynote speech on "Micro-chemical technology and continuous flow Synthesis"

Mr.Christian Bachofen, director of The Group, chief technology officer of biomedicine, and internationally renowned biomedical design and planning expert, has brought you the advanced layout concept and added value of the international biopharmaceutical plant on the topic of "Basic elements of biological plant design". He pointed out that the plant design should have to reduce the risk of error, ensure clean state and good product quality, and combined with the international advanced plant design examples put forward the concept of open and pressure difference, explained in detail the cell amplification area, cell culture area, inspection area, downstream process area and configuration area and filter area layout setting, for the biological pharmaceutical enterprises brought forward-looking ideas and ideas.

 

Christian Bachofen delivered a keynote speech on "International Design Concept Sharing of Frontier biopharmaceutical Factory"

Biomaterials is the green driving force for the transformation and upgrading of traditional industries, and also an important breakthrough for green development. At the forum, Professor Zhuang Yingping, dean of the School of Bioengineering of East China University of Science and Technology, delivered a keynote speech on "Bioreactors and Intelligent Biofabrication". She pointed out that the biological manufacturing industry is the focus of competition in the world today, and the bioreactor engineering is the key to the improvement of the biological manufacturing level. She shared the latest research results of the state key laboratory of biological reactor engineering —— based on process metabolic parameters and microphysiological parameters combined optimization research technology and application, for the audience explained the intelligent perception, intelligent analysis, intelligent execution and other five key technologies and practical cases, with industry cutting-edge technology to open the door of biological "wisdom" in the future.

 

Zhuang Yingping delivered a keynote speech on "Bioreactors and intelligent Biomaking"

At present, the information workers in the pharmaceutical industry are facing unprecedented technical challenges. How to leverage the new generation of information technology to promote the digital transformation process of enterprises is a common test faced by the industry. In the forum, Mr.Yang Yujie, manager of engineering and equipment Department of Beijing Sinovexing Biological Products Co., LTD., shared in depth "How to land in biopharmaceutical enterprises". He from the enterprise informatization planning blueprint, implementation route, organizational structure and other specific aspects, emphatically the bridge connecting OT and IT —— MES system construction, finally he showed the informatization after the pharmaceutical enterprise production management, material management, quality management, electronic record deliverables and value, for the biological pharmaceutical enterprise informatization landing provides a very reference guide to action.

 

Yang Yujie "How to implement the information system in biopharmaceutical enterprises" keynote speech

Industry, university and research common talk-relying on science and technology to realize the concept The combination of industry, university and research is the synergy and integration of resource advantages, but also the docking and coupling of the upstream, middle and downstream of technological innovation. In order to better help the industry to solve problems and take the road of high-quality development, there are two special industry-university-research dialogue links during this forum

 

From left to right, they are: Zhang Jinwei, Zhang Hua, Wang Xuegong, Chen Ping, Luo Guangsheng

In the industry-university-research dialogue section of "How to Realize Green Production and Innovation and Upgrading", in addition to the speakers Wang Xuegong, Chen Ping and Luo Guangsheng, Dr. Zhang Hua, president of Shanghai Chuangnuo Pharmaceutical Group, was specially invited to jointly explore the future production and development direction of chemical pharmaceutical enterprises. Dr. Zhang Hua said that the chemical pharmaceutical industry has been and will continue to differentiate and restructure the competitive pattern. At present, chemical API is faced with the bottlenecks of unreasonable industrial structure, insufficient innovation ability, serious product homogenization and low concentration. In the future development, chemical pharmaceutical enterprises should find the right positioning in the competition, reconstruct the industrial layout, compress the excess API capacity, and constantly combine new technological technologies to achieve green, low-carbon and intelligent development. In terms of green production of chemical and pharmaceutical enterprises, President Wang Xuegong pointed out that the long-standing green manufacturing problems in the industry should be solved through the transformation and application of advanced technology, and the regulatory level should better conform to the requirements of technological progress, and create a fair competition environment. In view of the characteristics of complex sewage treatment composition and large volume of pharmaceutical and chemical enterprises, Dr. Chen Ping believes that, first of all, the early classification, collection and pretreatment should have corresponding countermeasures, such as evaporation, concentration and salt desalination, free radical oxidation and other technologies. Secondly, according to the change of water quantity, the multi-unit design should be carried out, and on the basis of the universal process technology, targeted and specific measures should be used to solve the characteristics of the industry and the project. Professor Luo Guangsheng, combined with the concept of continuous synthesis technology, pointed out how to accelerate the transformation and application of technology in pharmaceutical enterprises from the establishment of national standards, the cultivation of talents and the support of equipment software and hardware. Finally, when looking forward to the future of the industry, the experts participating in this industry-university-research dialogue concluded that chemical drugs are still the main body of clinical drugs, and their status is unshakable. Innovation enterprises, enterprises with manufacturing advantages and enterprises with strong brand products can still have a stable foothold in the market in the future.

 

From left to right are: Zhang Jinwei, Wang Zejian, Christian Bachofen, Zhuang Yingping, Yang Yujie

In the biological drug research and development products how to quickly realize the industrialization of the dialogue plate, in addition to the speaker Christian Bachofen, ZhuangYingPing, Yang Yujie, also specially invited to the east China university of science and technology, associate professor of bioengineering, Shanghai lingang group biological medicine industrial park consultant ze-Ji'an wang, and speakers talk about the biomedical industry breakthrough and in the future. Christian compares the differences in Chinese and western biomedical design in terms of conceptual design, construction, commissioning, validation and verification, and risk assessment. He highlighted that the West is different from China in terms of concept design and basic design, and occupies a long time to optimize energy consumption and reduce carbon dioxide emissions, thus reducing later operating costs. Meanwhile, the verification will be long for reasonable verification. In the bioengineering talent training, Professor Zhuang Yingping analyzed both universities and enterprise, pointing out that we should actively introduce talents with engineering practice experience at the university level, and set higher requirements for students to practice as much as possible. At the enterprise level, it is necessary to pay attention to the training of technical backbone and hold targeted professional training. At the same time, it is also necessary to build a platform for the integration of industry and education, and entrust universities to train master's degrees and doctors of engineering in orientation, so as to directly solve the problems faced by enterprises at the present stage. Professor Wang Zejian explained in detail the public service level that a high-quality biomedical park should have through eight platforms, including industry-university-research incubation platform, public research and development platform, industry-education integration platform, and human resource platform. Finally, Mr.Yang Yujie analyzed the key bottlenecks that should be paid attention to in the industrialization process of biological products from three aspects: design level, the full life cycle of GMP management and risk assessment.

Sharing the new ecology in the cloud, the 15th Science and Technology Forum of 2022 has been perfectly concluded through online live streaming. It is the responsibility of the Forum to gather wisdom and reconstruct the industrial ecology; seeing the future, embracing the new life of the industry, and this mission will inject the strongest impetus into the continuous development of the industry, and become a moving movement to write a new ecological pattern to a new level.

Forum playback

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